By Jürg Müller
16 years is decades, not just in human existence but additionally within the swift background of up to date endocrinology. because the ebook of the 1st variation of this monograph, various new strains of analysis and discoveries have enormously contrib uted to our wisdom of the physiological and pathological law of aldos terone biosynthesis in guy and animals. the 1st reviews a couple of delicate ra dioimmunoassay for plasma aldosterone and a couple of education of dispersed zona glomerulosa cells have been released in 1970 (Mayes et al. 1970; Haning et al. 1970). those advancements on my own grew to become out to have an important impression on study in aldosterone body structure (for experiences see Coghlan et al. 1979b; J. F. Tait et al. 1980b). In 1971, atrial natriuretic peptides, somatostatin, and the precursor molecule of ACTH had now not but been stumbled on. Angiotensin antagonists and con verting-enzyme inhibitors weren't but to be had. The medical syndrome of hypo reninemic hypo aldosteronism was once unknown. the potential roles of prostaglandins and dopamine within the keep watch over of aldosterone pwduction had now not been thought of. Cyclic AMP used to be then the one substance with a truly confirmed second-mes senger functionality.
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