By K. Schrör (auth.), Prof. Dr. med. Curt Diehm, Prof. Dr. med. Helmut Sinzinger, Dr. med. Waltraud Rogatti (eds.)
Although prostaglandin El (PGE ) has been clinically on hand for a protracted 1 time, merely in recent times has its effectiveness in peripheral arterial occlusive disorder been proven in managed reports. now not unusually, the favour capable effects accomplished either in sufferers with serious limb ischaemia and in people with intermittent claudication has inspired study actions into the scientific pharmacology of this prostaglandin. by reason of those efforts, intriguing new findings have printed that PGE has anti thrombotic , endothelium-stabilizing and leucocyte-stabi 1 lizing homes in addition to results on lipid metabolism, all of which, fairly except its famous anti-aggregating and vasodilator results, could upload to the scientific efficacy of the substance. New facts have additionally been accrued at the metabolism of PGE such a lot b particularly the detection of 13,14-dihydro-PGE a metabolite which used to be b lately remoted in people following the management of PGE . Being 1 biologically lively, the pharmacodynamic spectrum of 13,14-dihydro-PGE 1 very heavily resembles that of PGE . This discovering might help to give an explanation for the 1 efficacy of PGE regardless of its quick metabolization whilst given intravenously.
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