By R. S. Reneman, P. A. J. Janssen (auth.), Prof. Dr. med. A. Doenicke (eds.)
The query how one can set off basic anaesthesia effortlessly has been requested again and again through anaesthetists and pharmacologists. P. A. JANSSEN built etomidate and released this substance in 1971 as "a effective short-acting and comparatively atoxic intravenous hypnotic agent in rats". In 1974 after a number of years of experimental and scientific trial the barbiturate-free hypnotic etomidate (soon advertised as Hypnomidate) was once brought to various auditors on the party of the IV. eu Congress of Anaesthesiologists in Madrid. because the authors prolonged their essays, the reality of the current e-book is given. the belief mentions the recent resolution of etomidate base in 35 % propylene glycol. it really is anticipated that the disadvantageous results - venous soreness in the course of injection and linked involuntary muscle stream- will mostly be eradicated by utilizing the recent formulation of etomidate after premedication of fentanyl. Mlinchen, August 1977 Alfred DOENICKE desk OF CONTENTS The Experimental Pharmacology of Etomidate, a brand new powerful, Short-Acting Intravenous Hypnotic (R. S. RENEMAN and P. A. JANSSEN) •. . . . •• 1 Protein Binding of Etomidate (G. A. MANNES and A. DOENICKE) ••••. . . 6 The influence of Intra-Arterial Injection of Etomidate and Thiopental at the Skeletal Muscle- and Arterial Wall-Structures (R. S. RENEMAN, F. VERHEYEN, R. KRUGER, W. VAN GERVEN and M. BORGES) . . •. . •• nine interplay among Etomidate and the Antihypertensive brokers Propanolol andoC-Methyl-Dopa (R. S. RENEMAN, W. VAN GERVEN and R. KRUGER) ••. •. . . 15 Teratogenicity of Etomidate (A. DOENICKE and M. HAEHL) •. ••. •.